Will Ferrell

Harold Crick

Maggie Gyllenhaal

Ana Pascal

Dustin Hoffman

Professor Jules Hilbert

Queen Latifah

Penny Escher

Emma Thompson

Karen Eiffel

Tony Hale

Dave

Tom Hulce

Dr. Cayly

Linda Hunt

Dr. Mittag-Leffler

Kristin Chenoweth

Book Channel Host

John M. Watson Sr.

TV Author

Guy Massey

IRS Co-Worker #2

T.J. Jagodowski

IRS Co-Worker #4

Peter Grosz

IRS Co-Worker #5

Tonray Ho

IRS Co-Worker #6

Christian Stolte

Young Boy's Father

Denise Hughes

Kronecker Bus Driver

Peggy Roeder

Polish Woman

Danny Rhodes

Bakery Employee #1

Linara Washington

Bakery Employee #2

Helen Young

Bakery Customer #1

Jarrett Sleeper

Bakery Customer #4

Larry Neumann Jr.

Homeless Man

John Mohrlein

Man with Hose

Bruce Jarchow

Commuter

Bradley Mott

Large Man on Bus

Keith Kupferer

Demolition Foreman

Danny McCarthy

Demolition Crew #1

Tab Baker

Demolition Crew #2

Ray Kurut

ER Doctor #2

Bryan Kelly

ER Orderly

Whitney Sneed

ER Nurse #1

Celeste Pechous

ER Nurse #2

Cheryl Lynn Bruce

Head ER Nurse

Ora Jones

Banneker Press Receptionist

Will Clinger

Accident Witness

Frank Caeti

Accident Witness

Andrew Rothenberg

Doctor Mercator

Bob Papenbrook

Animal Footage Voice Over (voice)

Mike McColl

Animal Footage Voice Over (voice)

Nathan Adloff

Bakery Patron (uncredited)

Sia A. Moody

Nurse #3 (uncredited)

Eli Goodman

Augustus Chatman (uncredited)