Joaquin Phoenix

Larry "Doc" Sportello

Josh Brolin

Lt. Det. Christian F. "Bigfoot" Bjornsen

Owen Wilson

Coy Harlingen

Katherine Waterston

Shasta Fay Hepworth

Reese Witherspoon

Deputy D.A. Penny Kimball

Benicio del Toro

Sauncho Smilax, Esq.

Jena Malone

Hope Harlingen

Joanna Newsom

Sortilège, who is also the narrator

Jordan Christian Hearn

Denis

Hong Chau

Jade

Jeannie Berlin

Aunt Reet

Maya Rudolph

Petunia Leeway

Michael Kenneth Williams

Tariq Khalil

Martin Short

Dr. Rudy Blatnoyd, D.D.S.

Sasha Pieterse

Japonica Fenway

Martin Donovan

Crocker Fenway

Eric Roberts

Michael Z. "Mickey" Wolfmann

Serena Scott Thomas

Sloane Wolfmann

Christopher Allen Nelson

Glenn Charlock

Sam Jaeger

Agent Flatweed

Timothy Simons

Agent Borderline

Jillian Bell

Chlorinda

Martin Dew

Dr. Buddy Tubeside

Shannon Collis

Bambi

Catherine Haena Kim

News Reporter

Yvette Yates Redick

Luz

Joe Dioletto

Cop with Bigfoot

Jack Kelly

Burke Stodger (archive footage)

Belladonna

Clancy Charlock

Elaine Tan

Xandra

Wilson Bethel

LAPD Officer #1

Anders Holm

LAPD Officer #2

Erica Sullivan

Dr. Lily Hammer

Eva Fisher

Dr. Threeply's Assistant #1

Jackie Michele Johnson

Dr. Threeply's Assistant #2

Katie Schwartz

Kimberly

Charley Morgan

Dr. Igor

Keith Jardine

Puck Beaverton

Delaina Mitchell

Mrs. Chastity Bjornsen

Peter McRobbie

Adrian Prussia

Samantha Lemole

Golden Fang Mother

Christian Williams

Smedley

Jefferson Mays

Dr. Threeply

David Prak

Buddhist Monk

Amy Ferguson

Bodhi

Emma Dumont

Zinnia

Christina Bobrowsky

Patient (uncredited)

Peter Bonilla

Police Officer (uncredited)

Marianne Bourg

Beach Girl (uncredited)

Laura Lyon Rossi

Groupie (uncredited)

Ashleigh Biller

Patient (uncredited)

Elizabeth Colunga

Patient (uncredited)

Nick de Graffenreid

Patient (uncredited)

Adam Dorsey

Jesus Guard (uncredited)

Ken Edling

Judge (uncredited)

Brandy Futch

Flight Attendant (uncredited)

Jessica Huss

Speed Freak (uncredited)

Robert Peoples

Patient (uncredited)

Christopher Karl Johnson

Mr. Robinson (uncredited)

Adeana Lane

Beach Girl (uncredited)

Kira Legg

Groupie (uncredited)

Blue LoLan

Patient (uncredited)

Amanda Maddox

Flight Attendant (uncredited)

Emilee Madrak

Groupie (uncredited)

Kirstin Masters

Dental Assistant (uncredited)

Chelsea O'Toole

Patient (uncredited)

Joel Shock

Police Officer (uncredited)

Matthew Skomo

Detective (uncredited)

Chantal Thuy

Groupie (uncredited)

Diana Elizabeth Torres

Lourdes (uncredited)