Seth MacFarlane

Albert

Charlize Theron

Anna

Amanda Seyfried

Louise

Liam Neeson

Clinch

Giovanni Ribisi

Edward

Neil Patrick Harris

Foy

Sarah Silverman

Ruth

Christopher Hagen

George Stark

Wes Studi

Cochise

Matt Clark

Old Prospector

Evan Jones

Lewis

Aaron McPherson

Ben

Rex Linn

Sheriff / Narrator

Brett Rickaby

Charlie Blanche

Alex Borstein

Millie

Ralph Garman

Dan

John Aylward

Pastor Wilson

Jay Patterson

Doctor Harper

Dennis Haskins

Snake Oil Salesman

Christopher Lloyd

Doc Brown

Gilbert Gottfried

Abraham Lincoln

Ewan McGregor

Cowboy at Fair

John Michael Higgins

Dandy #1

Julius Sharpe

Dandy #2

Mike Miller

Vendor

Alec Sulkin

Guy at Fair

Tatanka Means

Other Apache

Jean Effron

Elsie Stark

Bob Jesser

Cowboy at Table

Dylan Kenin

Pastor's Son

Mike Salazar

6 year old Albert

Jimmy Hart

Photographer

Joe Berryman

Teacher

Tait Fletcher

Cowboy #1

Kevin Wiggins

Ruth's Cowboy Client

Lydia Cash

Barn Dancer

Sarah O'Gleby

Barn Dancer

Kelsey Paschich

Barn Dancer

Andrew Pirozzi

Barn Dancer

Vladimir Conde Reche

Barn Dancer

Alex Michael Stoll

Barn Dancer

Jeremy Hudson

Barn Dancer

Alex Wong

Barn Dancer

Preston Bailey

12 Year Old Albert (uncredited)

Belle Shouse

12 Year Old Girl (uncredited)

Challen Cates

Female Passenger (uncredited)

Catherine Shu

Chinese Girl (uncredited)

Johnny Otto

Cowboy (uncredited)

Mae Whitman

Prostitute (uncredited)

Patrick Stewart

Dream Voice (voice) (uncredited)

Bill Maher

Barn Dance Comedian (uncredited)

Jamie Foxx

Django (uncredited)

Allyn Rachel

Wild Girl (uncredited)

Kaley Cuoco

Woman in the Store (uncredited)

Ryan Reynolds

Man Killed by Clinch in Bar (uncredited)