Colin Farrell

Alexander

Angelina Jolie

Olympias

Val Kilmer

Philip

Jared Leto

Hephaistion

Jonathan Rhys Meyers

Cassander

Anthony Hopkins

Old Ptolemy

Jessie Kamm

Young Alexander

Christopher Plummer

Aristotle

Connor Paolo

Young Alexander

Peter Williamson

Young Nearchus

Morgan Christopher Ferris

Young Cassander

Rob Earley

Young Ptolemy

Aleczander Gordon

Young Perdiccas

John Kavanagh

Parmenion

Gary Stretch

Cleitus

Rosario Dawson

Roxane

Toby Kebbell

Pausanius

Fiona O'Shaughnessy

Nurse

Laird Macintosh

Greek Officer

Francisco Bosch

Bagoas

Neil Jackson

Perdiccas

Rory McCann

Crateros

Raz Degan

Darius III

Joseph Morgan

Philotas

David Bedella

Scribe

Brian Blessed

Wrestling Trainer

Nick Dunning

Attalus

Elliot Cowan

Ptolemy

Ian Beattie

Antigonus

Denis Conway

Nearchus

Michael Dixon

Campfire Soldier

Tim Pigott-Smith

Omen Reader

Erol Sander

Persian Prince

Stéphane Ferrara

Bactrian Commander

Tadhg Murphy

Dying Soldier

Annelise Hesme

Stateira

Marie Meyer

Eurydice

Mick Lally

Horse Seller

Garrett Lombard

Leonnatus

Rab Affleck

Attalus' Henchman

Féodor Atkine

Roxane's Father

Bin Bunluerit

Indian King

Jaran Ngamdee

Indian Prince

Brian McGrath

Doctor

Michelle Lukes

Roxane Dancer

Anjali Mehra

Roxane Dancer

Benny Maslov

Bagoas Dancer

Benjamín Benítez

Amato (uncredited)

Nicolas D. Blake

Palace Page (uncredited)

Max Bollinger

Young Greek Official (uncredited)

Jason Croot

Peasant (uncredited)

Dale Dye

Macedonian Veteran at Hyphasis Speech (uncredited)

Abbie Hirst

Octavia (uncredited)

Charlie Hollway

Boy (uncredited)

Rowley Irlam

Pausanius's Accomplice (uncredited)

David Leon

Hermolaous (uncredited)

Greg Orvis

Celtic Diplomat (uncredited)

Lee Anthony Parnell

Warrior (uncredited)

John Reynolds

Dexapous (uncredited)

Oliver Stone

Macedonian Soldier at Zeus Statue (uncredited)