Diego Luna

Manolo (voice)

Zoe Saldaña

Maria (voice)

Channing Tatum

Joaquin (voice)

Ron Perlman

Xibalba (voice)

Christina Applegate

Mary Beth (voice)

Ice Cube

Candle Maker (voice)

Kate del Castillo

La Muerte (voice)

Héctor Elizondo

Carlos Sanchez (voice)

Danny Trejo

Skeleton Luis (voice)

Carlos Alazraqui

General Posada / Dali / Chuy (voice)

Ana de la Reguera

Skeleton Carmen (voice)

Elijah Rodriguez

Young Joaquin (voice)

Plácido Domingo

Skeleton Jorge (voice)

Jorge R. Gutierrez

Skeleton Carmelo (voice)

Eugenio Derbez

Chato (voice)

Gabriel Iglesias

Pepe Rodriguez (voice)

Dan Navarro

Chakal (voice)

Miguel Sandoval

Land of Remembered Captain (voice)

Grey DeLisle

Grandma (voice)

Ben Gleib

Goya / Dali (voice)

Cheech Marin

Pancho Rodriguez (voice)

Anjelah Johnson-Reyes

Adelita / Nina (voice)

Sandra Equihua

Scardelita (voice)

Gunnar Sizemore

Ignacio (voice)

Angélica María

Sister Ana (voice)

Eric Bauza

Father Domingo / Cave Guardian (voice)

Aron Warner

Thomas (voice)

Sandra Echeverría

Claudia (voice)

Tonita Castro

La Muerte as Old Woman (voice)

Troy Evans

Old Man Hemingway (voice)

Guillermo del Toro

Land of Remembered Captain's Wife (voice)

Brad Booker

Conductor (voice)

Rosemary Alexander

Additional Voices (voice)

Steve Alterman

Additional Voices (voice)

Eva Bella

Additional Voices (voice)

Vicki Davis

Additional Voices (voice)

Moosie Drier

Additional Voices (voice)

Cullen McCarthy

Additional Voices (voice)

David Michie

Additional Voices (voice)

Jonathan Nichols-Navarro

Additional Voices (voice)

Al Rodrigo

Additional Voices (voice)

Marcelo Tubert

Additional Voices (voice)

Lynnanne Zager

Additional Voices (voice)

Ruth Zalduondo

Additional Voices (voice)

Newell Alexander

Additional Voices (voice)

David Cowgill

Additional Voices (voice)

Elisa Gabrielli

Additional Voices (voice)

Richard Miro

Additional Voices (voice)

Arthur Ortiz

Additional Voices (voice)

Joe Matthews

Young Manolo (singing voice)

Jose Alvarez

Additional Voices (voice) (uncredited)