Diego Luna

Manolo (voice)

Channing Tatum

Joaquin (voice)

Zoe Saldaña

Maria (voice)

Christina Applegate

Mary Beth (voice)

Eugenio Derbez

Chato (voice)

Cheech Marin

Pancho Rodriguez (voice)

Gabriel Iglesias

Pepe Rodriguez (voice)

Ron Perlman

Xibalba (voice)

Kate del Castillo

La Muerte (voice)

Ana de la Reguera

Carmen Sánchez (voice)

Dan Navarro

Chakal (voice)

Ice Cube

Candle Maker (voice)

Hector Elizondo

Carlos Sanchez (voice)

Danny Trejo

Skeleton Luis (voice)

Carlos Alazraqui

General Posada / Dali / Chuy (voice)

Elijah Rodriguez

Young Joaquin

Plácido Domingo

Skeleton Jorge (voice)

Grey DeLisle

Grandmother (voice) (as Grey Griffin)

Miguel Sandoval

Land of the Remembered Captain (voice)

Ben Gleib

Goya / Dali (voice)

Jorge R. Gutierrez

Skeleton Carmelo (voice)

Anjelah Johnson-Reyes

Adelita / Nina (voice)

Sandra Equihua

Scardelita (voice)

Gunnar Sizemore

Ignacio (voice)

Angélica María

Sister Ana (voice)

Eric Bauza

Father Domingo / Cave Guardian (voice)

Aron Warner

Thomas (voice)

Sandra Echeverría

Claudia (voice)

Tonita Castro

La Muerte as Old Woman (voice)

Troy Evans

Old Man Hemingway (voice)

Guillermo del Toro

Land of the Remembered Captain's Wife (voice)

Brad Booker

Conductor (voice)

Rosemary Alexander

Additional Voices (voice)

Eva Bella

Additional Voices (voice)

Vicki Davis

Additional Voices (voice)

Moosie Drier

Additional Voices (voice)

Cullen McCarthy

Additional Voices (voice)

David Michie

Additional Voices (voice)

Jonathan Nichols

Additional Voices (voice)

Al Rodrigo

Additional Voices (voice)

Marcelo Tubert

Additional Voices (voice)

Lynnanne Zager

Additional Voices (voice)

Ruth Zalduondo

Additional Voices (voice)

Newell Alexander

Additional Voices (voice)

David Cowgill

Additional Voices (voice)

Elisa Gabrielli

Additional Voices (voice)

Richard Miro

Additional Voices (voice)

Arthur Ortiz

Additional Voices (voice)

Joe Matthews

Young Manolo (singer)

Jose Alvarez

Additional Voices (voice) (uncredited)