Will Smith

Dr. Bennet Omalu

Alec Baldwin

Dr. Julian Bailes

Albert Brooks

Dr. Cyril Wecht

Gugu Mbatha-Raw

Prema Mutiso

David Morse

Mike Webster

Arliss Howard

Dr. Joseph Maroon

Mike O'Malley

Daniel Sullivan

Eddie Marsan

Dr. Steven DeKosky

Hill Harper

Christopher Jones

Adewale Akinnuoye-Agbaje

Dave Duerson

Stephen Moyer

Dr. Ron Hamilton

Richard T. Jones

Andre Waters

Paul Reiser

Dr. Elliot Pellman

Luke Wilson

Roger Goodell

Matthew Willig

Justin Strzelczyk

Elizabeth Tulloch

Keana Strzelczyk

Jason Davis

Defense Attorney

Sara Lindsey

Gracie

Kevin Jiggetts

FBI Agent

Gary Grubbs

FBI Agent

L. Scott Caldwell

Waters' Mother

Joni Bovill

Mrs. Scott

Joshua Elijah Reese

Graveyard Tech

Holt McCallany

Angry Neurologist

Kelley Davis

Assistant

Samara Lee

Strzelczyk's Daughter

Nathan Hollabaugh

Young Reporter

Britanni Johnson

Rachel Green

Randy Kovitz

Deputy Mayor

Dan Ziskie

Paul Tagliabue

Larry John Meyers

Father D'Amico

Jared Pfennigwerth

Tech

Phillip Chorba

Tech

Cindy Jackson

Paramedic

Joe Fishel

Louisville Head Football Coach

Brittney Aleah

Altar Server (uncredited)

Christopher Boyer

Crockett (uncredited)

Carmen Gangale

Doctor (uncredited)

Eme Ikwuakor

Amobi Okoye (uncredited)

Robert G. McKay

Mr. Scott (uncredited)

F. Robert McMurray

NFL Lawyer (uncredited)

Jared Scott

Justin Strelczyk (uncredited)