Tom Cruise

Frank T.J. Mackey

Philip Baker Hall

Jimmy Gator

Philip Seymour Hoffman

Phil Parma

Julianne Moore

Linda Partridge

William H. Macy

Quiz Kid Donnie Smith

John C. Reilly

Officer Jim Kurring

Melora Walters

Claudia Wilson Gator

Jeremy Blackman

Stanley Spector

Jason Robards

Earl Partridge

Melinda Dillon

Rose Gator

Michael Bowen

Rick Spector

April Grace

Gwenovier

Ricky Jay

Burt Ramsey / Narrator

Pat Healy

Sir Edmund William Godfrey / Young Pharmacy Kid

Neil Flynn

Stanley Berry

Rod McLachlan

Daniel Hill

Allan Graf

Firefighter

Patton Oswalt

Delmer Darion

Brad Hunt

Craig Hansen

Jim Meskimen

Forensic Scientist

Chris O'Hara

Sydney Barringer

Clement Blake

Arthur Barringer

Jim Ortlieb

Middle-Aged Guy

Thomas Jane

Young Jimmy Gator

Veronica Hart

Dentist Nurse #1

James Kiriyama-Lem

Dr. Lee

Jake Cross

Pedestrian #1

John Pritchett

Police Captain

Cleo King

Marcie

Don McManus

Dr. Landon

Michael Shamus Wiles

Captain Muffy

Jason Andrews

Doc

John S. Davies

Cameraman

Kevin Breznahan

Geoff, Seminar Guy

Miguel Pérez

Avi Solomon

Alfred Molina

Solomon Solomon

Neil Pepe

Officer #1

Lionel Mark Smith

Detective

Annette Helde

Coroner Woman

Felicity Huffman

Cynthia

Scott Burkett

WDKK Page #1

Danny Wells

Dick Jennings

Eileen Ryan

Mary

Meagen Fay

Dr. Diane

Luis Guzmán

Luis

Orlando Jones

Worm

Henry Gibson

Thurston Howell

Natalie Elizabeth Marston

Julia

Clark Gregg

WDKK Floor Director

Matt Gerald

Officer #2

Paul F. Tompkins

Chad (Seduce & Destroy) (voice)

Mary Lynn Rajskub

Janet (Frank's Assistant) (voice)

Jim Beaver

Smiling Peanut Patron #1

Ezra Buzzington

Smiling Peanut Patron #2

Michael Murphy

Alan Kligman, Esq.

Robert Downey Sr.

WDKK Show Director

William Mapother

WDKK Show Director's Assistant

Mike Massa

Paramedic #2

Dale Gibson

Paramedic #3

Scott Alan Smith

E.R. Doctor

Paul Thomas Anderson

Man Confiscating Sign (uncredited)

Miriam Margolyes

Faye Barringer (uncredited)

Robert Bella

Detective #2 (uncredited)

Greg Bronson

Waiter (uncredited)

Phil Hawn

Bob (uncredited)

Spencer Kayden

Seminar Patron (uncredited)

Aimee Mann

Hot Date Infomercial (uncredited)

Tom Ohmer

Detective (uncredited)