Cate Blanchett

Bernadette

Billy Crudup

Elgie

Kristen Wiig

Audrey

Judy Greer

Dr. Kurtz

Laurence Fishburne

Paul Jellinek

Emma Nelson

Bee

Troian Bellisario

Becky

James Urbaniak

Agent Marcus Strang

Megan Mullally

Judy Toll

Richard Robichaux

Floyd the Pharmacist

Kate Burton

Ellen Idelson

Steve Zahn

David Walker

David Paymer

Jay Ross

Zoë Chao

Soo-Lin

Patrick Sebes

Tom the Blackberry Guy

Patrick Jordan

Game Show Host

Kathryn Feeney

Tamara the Pharmacy Employee

Daina Griffith

Julie Prospective Parent

Kate Easton

Tammy Prospective Parent

Thalia Torio

Kennedy

Jóhannes Haukur Jóhannesson

Captain J. Rouverol

Claudia Doumit

Iris

Katelyn Statton

Vivian

Joe Coyle

Mike the State Senator

Richard Barlow

Stu Reardon (Microsoft Executive) (uncredited)

Kelley Davis

Passenger (uncredited)

Russell Bradley Fenton

Gary Oppenheimer (uncredited)

Joe Fishel

Galer Street School Parent (uncredited)

F. Robert McMurray

Airplane Passenger (uncredited)

Lana Young

Elaine the Airline Woman (uncredited)