Hank Azaria

Gargamel

Neil Patrick Harris

Patrick Winslow

Jayma Mays

Grace Winslow

Jonathan Winters

Papa Smurf (voice)

Katy Perry

Smurfette (voice)

Anton Yelchin

Clumsy Smurf (voice)

Sofía Vergara

Odile Anjelou

Tim Gunn

Henri

Frank Welker

Azrael (voice)

Madison McKinley

Model

Meg Phillips

Model

Mahadeo Shivraj

Cabbie

Mark Doherty

Bluetooth Businessman

Minglie Chen

Young Woman

Sean Kenin

Guy in Plaid Shirt

Victor Pagan

Bum

Paula Pizzi

Odile's Mother

Andrew Sellon

Waiter

Julianna Rigoglioso

Little Sister

Bradley Gosnell

Toy Salesperson

Heidi Armbruster

Toy Store Parent

John Speredakos

Parent with Girls

Skai Jackson

Kicking Girl

Jojo Gonzalez

FAO Custodian

Scott Dillin

Cop

Sean Ringgold

Inmate Bubba

Mario D'Leon

Bubba's Inmate Friend

Liz Smith

Party Guest

Tom Colicchio

Party Guest

Michael Musto

Party Guest

Joan Rivers

Party Guest

Olivia Palermo

Party Guest

Alan Cumming

Gutsy Smurf (voice)

Fred Armisen

Brainy Smurf (voice)

George López

Grouchy Smurf (voice)

Kenan Thompson

Greedy Smurf (voice)

Jeff Foxworthy

Handy Smurf (voice)

John Oliver

Vanity Smurf (voice)

Wolfgang Puck

Chef Smurf (voice)

Gary Basaraba

Hefty Smurf (voice)

Paul Reubens

Jokey Smurf (voice)

B.J. Novak

Baker Smurf (voice)

Tom Kane

Narrator Smurf (voice)

John Kassir

Crazy Smurf (Voice)

Joel McCrary

Farmer Smurf (voice)

Mary McGloin

Mother of Girl in Store (uncredited)

Gérard Hernandez

(voice) (uncredited)

Cœur de Pirate

(voice) (uncredited)

Lorànt Deutsch

(voice) (uncredited)