Claudette Colbert

Cleopatra

Warren William

Julius Caesar

Henry Wilcoxon

Marc Antony

Joseph Schildkraut

King Herod

Ian Keith

Octavian

Gertrude Michael

Calpurnia

C. Aubrey Smith

Enobarbus

Irving Pichel

Apollodorus

Arthur Hohl

Brutus

Edwin Maxwell

Casca

Leonard Mudie

Pothinos

Ferdinand Gottschalk

Glabrio (scenes deleted)

Claudia Dell

Octavia

Harry Beresford

Soothsayer

Jayne Regan

Lady Vesta

William Farnum

Lepidus

Lionel Belmore

Fidius

Florence Roberts

Lady Flora

Richard Alexander

General Philodemas

William V. Mong

Court Physician

Robert Warwick

General Achillas

George Walsh

Courier

Wedgwood Nowell

Scribe

Robert Seiter

Aelius

Edgar Dearing

Convict

John Carradine

Roman Citizen/Party Guest/Soldier (uncredited) (voice)

Wilfred Lucas

Roman Greeting Antony (uncredited)

David Niven

Slave (uncredited)

Olga Celeste

Slave Girl (uncredited)

Ynez Seabury

Undetermined Role (uncredited)

Leon Beaumon

Egyptian Guard (uncredited)

Carlyle Blackwell Jr.

Undetermined Role (uncredited)

Marjorie Bonner

Roman Girl (uncredited)

Edmund Burns

Roman (uncredited)

Horace B. Carpenter

Roman (uncredited)

Neal Hart

Slave (uncredited)

Shep Houghton

Roman Soldier (uncredited)

Julanne Johnston

Undetermined Role (uncredited)

Darby Jones

Fan Bearer (uncredited)

Lillian Leighton

Onlooker at Procession (uncredited)

Mary MacLaren

Roman Woman (uncredited)

John Merton

Roman Guard (uncredited)

Juanita Moore

Dancer / Slave Girl (uncredited)

Jack Mulhall

Roman Greeting Antony (uncredited)

Hal Price

Onlooker at Procession (uncredited)

Jack Rutherford

Drussus (uncredited)

Phillips Smalley

Roman (uncredited)

Dale Van Sickel

Roman Soldier (uncredited)

Bryant Washburn

Undetermined Role (uncredited)

Blue Washington

Nubian Guard (uncredited)