Tobey Maguire

Spider-Man / Peter Parker

Kirsten Dunst

Mary Jane Watson

James Franco

New Goblin / Harry Osborn

Thomas Haden Church

Sandman / Flint Marko

Topher Grace

Venom / Eddie Brock

Bryce Dallas Howard

Gwen Stacy

Rosemary Harris

May Parker

J.K. Simmons

J. Jonah Jameson

James Cromwell

Captain Stacy

Dylan Baker

Dr. Curt Connors

Theresa Russell

Emma Marko

Bill Nunn

Joseph 'Robbie' Robertson

Bruce Campbell

Maître D'

Elizabeth Banks

Miss Brant

Ted Raimi

Hoffman

Perla Haney-Jardine

Penny Marko

Willem Dafoe

Green Goblin / Norman Osborn

Cliff Robertson

Ben Parker

Elya Baskin

Mr. Ditkovitch

Mageina Tovah

Ursula

John Paxton

Houseman

Becky Ann Baker

Mrs. Stacy

Stan Lee

Man in Times Square

Michael Papajohn

Dennis Carradine / Carjacker

Joe Manganiello

Flash Thompson

Lucy Gordon

Jennifer Dugan

Steve Valentine

Photographer

Tim Maculan

Play Director

Marc Vann

Play Producer

Joe Bays

Jazz Club Manager

Gregg Daniel

Precinct Detective

Rogelio T. Ramos

Emergency Room Doctor

Timothy Patrick Quill

Crane Operator

Kathryn Bryding

Woman Outside Theater

Joe Virzi

Police Detective

Bill E. Rogers

New Jersey State Policeman

April Parker Jones

Test Site Technician

Edward Padilla

Test Site Technician

Robert Curtis Brown

Test Site Technician

Terrell Clayton

Test Site Technician

Carolyn Neff

Test Site Technician

Christina Cindrich

Test Site Technician

Sonya Maddox

ICU Nurse

Andre B. Blake

Crane Disaster Radio Policeman

Emilio Rivera

Policeman at Sand Truck

Reynaldo Gallegos

Armored Car Driver

Jim Coope

Newstand Patron

Dean Edwards

Newsstand Patron

Margaret Laney

Newsstand Patron

Toni Wynne

Congratulatory Woman at Daily Bugle

Tanya Bond

Jazz Club Waitress

Mark Kubr

Jazz Club Bouncer

Emma Raimi

Girl With Camera

Dan Callahan

Jazz Club Musician

Ron King

Jazz Club Musician

Frank Anello

NYPD Officer (uncredited)

Anya Avaeva

Model (uncredited)

David Backus

Bucket Boy (uncredited)

John Crann

Theater Patron (uncredited)

Amy V. Dewhurst

Columbia Grad Student (uncredited)

Keith Fausnaught

Pedestrian (uncredited)

Logan Fry

Automobile Driver (uncredited)

Andrew James Jones

Jazz Club Bouncer (uncredited)

Natalie Jones

Girl at Key Ceremony (uncredited)

Bernadette Lords

British Publicist (uncredited)

Natalie McNeil

Girl Screaming in Camaro (uncredited)

Martha Millan

Oscorp Receptionist (uncredited)

Jen Oda

Beautiful Girl (uncredited)

Anjelia Pelay

Beautiful Woman (uncredited)

Vanessa Reseland

Beautiful Woman (uncredited)

La Rivers

Beautiful Woman (uncredited)

Vanessa Ross

Sandman Victim (uncredited)

Shade Rupe

City Hall Cheerer (uncredited)

Jennifer Sparks

Jazz Club Waitress (uncredited)

Christopher Stadulis

NY Firefighter (uncredited)

Evelyn Vaccaro

Beautiful Woman (uncredited)

Jennifer Weston

ER Nurse (uncredited)

Craig 'Radio Man' Castaldo

Radioman (uncredited)