Charlize Theron

Mavis Gary

Patton Oswalt

Matt Freehauf

Patrick Wilson

Buddy Slade

Elizabeth Reaser

Beth Slade

Collette Wolfe

Sandra Freehauf

Jill Eikenberry

Hedda Gary

Richard Bekins

David Gary

Mary Beth Hurt

Jan

Kate Nowlin

Mary Ellen Trantowski

Jenny Dare Paulin

Nipple Confusion Bassist

Louisa Krause

Front Desk Girl

Elizabeth Ward Land

Sales Lady

Brian McElhaney

Book Associate

Hettienne Park

Vicki

John Forest

Wheelchair Mike

Rightor Doyle

Babysitter

Brady Smith

Date Man

Tim Young

Champions Server

Erin Darke

Teen Employee

Jee Young Han

Teen Employee

Ella Rae Peck

Girl

Aleisha Allen

Girl

Orlagh Cassidy

Party Guest

Charles Techman

Parking Attendant

Emily Meade

Denny's Waitress

Neil Hellegers

Young Dad

Michael Nathanson

Champions Greeter

J.K. Simmons

Mavis' Publisher (voice) (uncredited)

Joel Thingvall

Businessman in Skyway (uncredited)

Rosemary Howard

Guest at Baby Naming Party (uncredited)