Leonardo DiCaprio

Dr. Randall Mindy

Jennifer Lawrence

Kate Dibiasky

Meryl Streep

President Orlean

Cate Blanchett

Brie Evantee

Rob Morgan

Dr. Teddy Oglethorpe

Jonah Hill

Jason Orlean

Mark Rylance

Peter Isherwell

Tyler Perry

Jack Bremmer

Timothée Chalamet

Yule

Ron Perlman

Benedict Drask

Ariana Grande

Riley Bina

Kid Cudi

DJ Chello

Himesh Patel

Phillip

Melanie Lynskey

June Mindy

Michael Chiklis

Dan Pawketty

Tomer Sisley

Adul Grelio

Paul Guilfoyle

General Themes

Robert Joy

Congressman Tenant

Jack Alberts

Oliver

Lance A. Williams

Daniel

Shimali de Silva

Nisha

Hettienne Park

Dr. Calder

Rafael Silva

Nasa Scientist

Lonnie Farmer

Old Aide #1

Rena Maliszewski

Anchor Reporting On Colon

Erik Parillo

Sherriff Conlon

Conor Sweeney

Marshall Mindy

Ross Partridge

Keith Ollens

Liev Schreiber

Bash Narrator (voice)

Samsara Yett

Isherwell Child Aide

Meara Mahoney Gross

Isherwell Child Aide

Staci Roberts

Linda Dicalio

Chris Everett

Chief Editor Paula Woods

Annette Miller

Mrs. Tanken

Stephen Thorne

Benjamin

Natalie Rebenkoff

Talent PA

Gary Tanguay

News Anchor #2

Georgia Lyman

Groomer Thalia

Ben Sidell

Stage Manager

Therese Plaehn

Autopsy Editor In Charge

Omar Ghonim

Damian

Meghan Leathers

Media Quant

Sarah Silverman

Sarah Benterman

Richard Snee

Senator Lerner

Jon Glaser

Meow Man

Dorothy Dwyer

Old Tough Lady

Alvin Keith

Harrison Telms

Lizzie Short

French Reporter

Sujoy De

Hindi Reporter

Lewis D. Wheeler

Mission Coordinator

Steve Gagliastro

Onlooker

David J. Curtis

Guy

Kevin Craig West

Secretary of State

Rob Lévesque

Secretary of Interior

Dee Nelson

Dr. Lisa Inez

Rebecca Gibel

Waitress

Brian Faherty

Guy from the Bar

Celeste Oliva

Nearby Diner

Roman Mitichyan

Rioting Patron

Alex Huynh

Rioting Patron

Michael Jibrin

Federal Agent

Bill Mootos

Federal Attorney

Patti Tippo

French President

Caroline Bergwall

Teen Girl Friend

Nate Richman

Stocky FBI Agent

John Bucy

Don't Look Up'er

Patrick Michael Strange

Just Look Up'er

Bianca de la Garza

Entertainment Journalist

Lance Norris

Loyal Supporter

Frank Ridley

Flight Director

Ishaan Khatter

Raghav Manavalan

Zach Holmes

#LaunchChallenge MeTuber (uncredited)

Chris Evans

Devin Peters (uncredited)

Marissa Carpio

Reporter with Big Hair (uncredited)

Luan Gallagher

Boy looking at the meteor. (Uncredited)

Clara Kovacic

(Uncredited)