Steve Carell

Gru (voice)

Kristen Wiig

Lucy (voice)

Benjamin Bratt

Eduardo / El Macho (voice)

Miranda Cosgrove

Margo (voice)

Dana Gaier

Edith (voice)

Elsie Fisher

Agnes (voice)

Russell Brand

Dr. Nefario (voice)

Ken Jeong

Floyd (voice)

Steve Coogan

Silas (voice)

Moisés Arias

Antonio (voice)

Nasim Pedrad

Jillian (voice)

Kristen Schaal

Shannon (voice)

Pierre Coffin

Kevin / Bob / Stuart / Additional Minions / Evil Minions (voice)

Chris Renaud

Additional Minions / Evil Minions / Italian Waiter (voice)

Nickolai Stoilov

Arctic Lab Guards (voice)

Vanessa Bayer

Flight Attendant (voice)

Ava Acres

Additional Voices (voice)

Lori Alan

Additional Voices (voice)

Jack Angel

Additional Voices (voice)

Eva Bella

Additional Voices (voice)

Georgia Cook

Additional Voices (voice)

John Cygan

Additional Voices (voice)

Debi Derryberry

Additional Voices (voice)

Jess Harnell

Additional Voices (voice)

Danny Mann

Additional Voices (voice)

Mona Marshall

Additional Voices (voice)

Mickie McGowan

Additional Voices (voice)

Mason McNulty

Additional Voices (voice)

Alec Medlock

Additional Voices (voice)

Laraine Newman

Additional Voices (voice)

Jan Rabson

Additional Voices (voice)

Andre Robinson

Additional Voices (voice)

Katie Silverman

Additional Voices (voice)

Casey Simpson

Additional Voices (voice)

Claira Nicole Titman

Additional Voices (voice)

Jim Ward

Additional Voices (voice)

April Winchell

Additional Voices (voice)

Joe Matthews

Additional Voices (voice)

Rob Tinkler

Purple Minions (voice) (uncredited)