Johnny Depp

Donnie Brasco / Joseph D. 'Joe' Pistone

Al Pacino

Benjamin 'Lefty' Ruggiero

Michael Madsen

Dominick 'Sonny Black' Napolitano

Bruno Kirby

Nicholas 'Nicky' Santora

James Russo

Paulie

Anne Heche

Maggie Pistone

Zeljko Ivanek

Tim Curley

Brian Tarantina

Bruno

Rocco Sisto

Richard 'Richie' Gazzo

Zach Grenier

Dr. Berger

Gerry Becker

Agent Dean Blandford FBI

Robert Miano

Alphonse 'Sonny Red' Indelicato

Paul Giamatti

FBI Technician

Gretchen Mol

Sonny's Girlfriend

Tim Blake Nelson

FBI Technician

Walt MacPherson

Sheriff

Ronnie Farer

Annette

Terry Serpico

Strip Club Owner

Tony Lip

Philip 'Philly Lucky' Giaccone

Val Avery

Santo Trafficante Jr.

Katie Sagona

Daughter

Larry Romano

Tommy

James McCauley

FBI Agent

Andrew Parks

Hollman

Rocco Musacchia

Trafficante's Man

Sal Jenco

Mare Chiaro Bartender

Denise Faye

Mob Girlfriend

Elaine del Valle

Mob Girlfriend

John Horton

FBI Director

Frank Pesce

Wiseguy

Randy Jurgensen

Wiseguy

John Di Benedetto

Wiseguy

Tony Ray Rossi

Wiseguy

Gaetano LoGiudice

Wiseguy

Flint Beverage

Kings Court Cop (uncredited)

Teresa Giudice

Shocked Stripper (uncredited)

Jim Lavin

Arresting FBI Officer (uncredited)

Peter O'Hara

Passerby (uncredited)

Antone Pagán

Prison Guard for Pacino and Depp (uncredited)

Garry Pastore

Carmine Galante's Bodyguard

Dale Resteghini

Strip Club Patron (uncredited)

Elle Alexander

Mob Girlfriend

Frankie Cee

Civilian (uncredited)