Edward Norton

Will Graham

Anthony Hopkins

Hannibal Lecter

Ralph Fiennes

Francis Dolarhyde

Emily Watson

Reba McClane

Harvey Keitel

Jack Crawford

Philip Seymour Hoffman

Freddy Lounds

Anthony Heald

Dr. Chilton

Mary-Louise Parker

Molly Graham

Tyler Patrick Jones

Josh Graham

Ken Leung

Lloyd Bowman

Frankie Faison

Barney

Lalo Schifrin

Conductor

John Rubinstein

Dinner Guest

David Doty

Dinner Guest

Brenda Strong

Dinner Guest

Robert Curtis Brown

Dinner Guest

Mary Anne McGarry

Dinner Guest

Veronica De Laurentiis

Dinner Guest

Michael Cavanaugh

Forensic Dentist

Madison Mason

Police Commissioner

Bill Duke

Police Chief

Cliff Dorfman

Cop

Tom Verica

Charles Leeds

Marguerite MacIntyre

Valerie Leeds

Thomas Curtis

Billy Leeds

Azura Skye

Bookseller

Jeanine Jackson

Dr. Hassler

William Lucking

Byron Metcalf

Katie Rich

Woman Detective

Ellen Burstyn

Grandma Dolarhyde (voice) (uncredited)

Mary Beth Hurt

Museum Curator (uncredited)

James Pickens Jr.

Male Zoo Doctor (uncredited)

Frank Whaley

Ralph Mandy (uncredited)

Tanya Newbould

Chromalux Secretary

Elizabeth Dennehy

Beverly

Joseph Simmons

Janitor

Mark Moses

Father in Video

Alex D. Linz

Young Dolarhyde (voice)

Andreana Weiner

Dr. Bloom's Secretary

Stanley Anderson

Jimmy

Gianni Russo

Newsie

Al Brown

Tattler Guard

Dwier Brown

Mr. Jacobi

Hillary Straney

Museum Secretary

Christopher Curry

Mr. Fisk

Conrad E. Palmisano

Deputy in Car