Jim Carrey

Lloyd Christmas

Jeff Daniels

Harry Dunne

Laurie Holden

Adele

Rachel Melvin

Penny

Kathleen Turner

Fraida

Rob Riggle

Travis / Captain Lippincott

Tembi Locke

Dr. Walcott

Paul Blackthorne

Emergency Room Doctor

Brady Bluhm

Billy

Patricia French

Ms. Sourpuss

Steve Tom

Dr. Pinchelow

Don Lake

Dr. Meldman

Eddie Shin

Gordy

Atkins Estimond

Gus

Tommy Snider

Tom

Lindsay Ayliffe

Professor Garabedian

Matthew Cardarople

Inventor No. 1

Bill Murray

Ice Pick

Grant James

Mr. Stainer

Taylor St. Clair

Mrs. Steiner

Erin Allin O'Reilly

Asylum Nurse No. 1

Erika Bierman

Fanny at Age 13

Kassidy Claire

Fanny at Age 5

Carly Craig

Young Fraida

Dalton E. Gray

Young Harry

June Shannon

Harry's Trailer Park Wife

Maia Moss-Fife

Receptionist

Jeff Sumner

Convention Official

Julius Sharpe

KEN Conference Attendee

Elizabeth Cooper

Mrs. Julie James

Michael Yama

Harry's Dad

Swizz Beatz

Ninja Leader

Mike Cerrone

Trucker

Sean Gildea

Trucker's Pal

Brett Wyman

Inventor #2

Jo Helton

Mrs. Snergle

Edward Barbanell

Nursing Home Orderly

Jon Barinholtz

Inventor No. 3

Sandra Dorsey

Stuffy Woman

Arielle Liberman

Emergency Room Nurse

Daniel Greene

Wheelchair Ninja

Danny Murphy

Joystick Victim

Gregory Fears

Man at Gas Station (uncredited)

Walter Hendrix III

Street Patron (uncredited)

Angela Kerecz

Waitress (uncredited)

John Merical

Neighbor (uncredited)

Rhomeyn Johnson

Bus Driver

Nancy Yee

Harry's Mom