Lindsay Lohan

Cady Heron

Rachel McAdams

Regina George

Lizzy Caplan

Janis Ian

Lacey Chabert

Gretchen Wieners

Amanda Seyfried

Karen Smith

Daniel Franzese

Damian

Jonathan Bennett

Aaron Samuels

Rajiv Surendra

Kevin Gnapoor

Tina Fey

Ms. Norbury

Tim Meadows

Mr. Duvall

Ana Gasteyer

Cady's Mom

Neil Flynn

Cady's Dad

Amy Poehler

Mrs. George

Dwayne Hill

Coach Carr

Diego Klattenhoff

Shane Oman

Molly Shanahan

Kristen Hadley

Elana Shilling

Spelling Girl

Ely Henry

Homeschooled Boy

Jonathan Malen

Kristen's Boyfriend

Miranda Edwards

Michigan Girl

Les Porter

Chemistry Teacher

Eve Crawford

English Teacher

Jack Newman

History Teacher

Ky Pham

Trang Pak

Daniel DeSanto

Jason

Alisha Morrison

Lea Edwards

Chris Anton

Huge Guy

Jan Caruana

Emma Gerber

Wai Choy

Mathlete Tim Pak

Julia Chantrey

Amber D'Alessio

Olympia Lukis

Jessica Lopez

Stefanie Drummond

Bethany Byrd

Kristen Bone

Short Girl

Andreja Punkris

Animal Dancer

Jordan Dawe

Animal Dancer

Laura de Carteret

Mrs. Wedell

Nicole Crimi

Kylie George

Erin Norah Thompson

Dawn Schweitzer

Dan Willmott

Mr. George

Sharron Matthews

Joan the Secretary

Jill Morrison

Crying Girl

Clare Preuss

Caroline Krafft

Bruce Hunter

Mathlete Moderator

David Reale

Glenn Coco (uncredited)

Krysta Carter

Wannabe (uncredited)