Danny DeVito

Frank Menure

Kathy Bates

Agnes Menure

Ron Livingston

Dr. Richard Clayton

Neve Campbell

Ellen Minnola

Beverly D'Angelo

Angela Minnola

Bob Odenkirk

Mitch Clayton

Edward Herrmann

Doug Clayton

Christine Baranski

Arleen Clayton

Martin Mull

Jeffry Morton

Michael McKean

Ken Hyman

M.C. Gainey

Spicer

Star Jones

Holly Davis

Ed Begley Jr.

Mr. Manoire

Debbi Morgan

Mrs. Manoire

Rose Abdoo

Frustrated Housewife

Connie Sawyer

Old Lady

Tracey Walter

Toupee Salesman

Sam Rubin

TV Anchorman

Dave Bautista

Wrestler (uncredited)

Jordan Brower

Prisoner (uncredited)

Jon Donahue

Additional voices (uncredited)

Paul Lévesque

Wrestler (uncredited)