Michael Cera

Fred

Jamie Kennedy

Mateus

Matthew Lillard

Self

Frankie Muniz

Chuck

Ryan Pinkston

Mike

Patrick J. Adams

Male Voice (voice)

Denise Boutte

New Tabitha

Rich Ceraulo Ko

Angus

Vanessa Lee Chester

Charlotte

Dennis Cockrum

Len's Dad

Byron Cotton

David

Nicholas D'Agosto

Evan

Christina DeRosa

Nancy

James Eckhouse

Jessica's Dad

John Farley

Mr. Matthews

Meagen Fay

Len's Mom

Ben Feldman

Len

Dan Finnerty

Gigundocock

Adam Frost

Male College Student

Simona Fusco

Hot Blonde

JoAnna Garcia Swisher

Sweetie-Pie

Kyle Gass

Director

Dona Hardy

Molly

Danneel Ackles

Melissa

Hank Harris

Ronny

Margo Harshman

Ted's Girlfriend

Kevin Hart

Barry

Heather Hogan

Kat

Kyle Howard

Boyfriend

Donna Kimball

Blue Bally (voice)

Vanessa Lengies

Carla

Philip Lenkowsky

Clerk

Bobbi Sue Luther

Gabriela

Sonia Rockwell

Kim

Cristin Michele

Jackie

Andy Milonakis

Justin

Beverley Mitchell

Sue

Steven Christopher Parker

Doug

Marcus T. Paulk

Wyatt

Rob Pinkston

Griffin

Jake Sandvig

Hank

Ashley Schneider

Betty

Rachel Specter

Blonde

Mindy Sterling

Jane

Jeremy Suarez

RJ

Ed Trotta

Lincoln

Kira Verrastro

Chick

Katie Walder

Drunk Girl

Rheagan Wallace

Jessica

Jermaine Williams

Leon

Cherilyn Wilson

Stacy

Mika Winkler

Little Person #3

Chris Cooper

FBI Agent Mike (uncredited)

Aaron Haedt

Guy in Underwear (uncredited)

John Westernoff

Guy in Underwear (uncredited)